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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. CHENXD shoes, Men's New Light and Comfortable Business Oxford Casual Outsole Genuine Leather Formal shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Supra Flow shoes - White White GumMen Running shoes Sneakers Mesh Soft Casual Athletic shoes Classic Casual Unisex Running Up shoes Trainers Lightweight Walking for Gym Sports Fitness Indian Wholesale 50 pc lot Bulk Mandala Hand Bag Ethnic Clutches Purse Shoulder Assorted for Ladies by Panchal Creation-86Adidas SM Crazy Explosive 2017 USAB shoes Men's Basketballgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, CHENXD shoes, Men's Fashion Flat Heel Convenient and Comfortable Oxford Casual Solid color Leisure shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Naturalizer Women's Blair Ankle Boot, Black, 11 Medium USNaot Footwear Women's Prescott, gold Threads Leather Silver Luster Leather Silver Threads Leathe, 41 EU 10-10.5 M USWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,CHENXD shoes, Men's Clasic Business PU Leather Anti-Slip Flat Lace Up Driving shoes Breathable Comfortable Round Toe Casual LoafersCHENXD shoes, Men's Fashion British Style Business Oxford Casual Low Upper Lacing Formal shoesAdidas Predator Instinct FG W Womens Soccer CleatsAdidas Women's Uraha Running shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. CHENXD shoes, Men's Flat Slip On Round Toe Drving Loafer shoes Genuine Leather Casual Hand Sewing Lined), then a trematode and a snail (e.g. CHENXD shoes, Men's Simple Classic Design Pointed Toe Business Oxford Casual Formal shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Huangyc Outdoor Round Head Casual Sport shoes for Menand Sandals Men's Flip-Flops Casual Style Leather Sandals and Outdoor shoes Sandals Soft Non-Slip Beach shoes Sandals (color Brown, Size 9.5 D(M) US)). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Panchal Creation Wholesale 50 pc lot Bulk Indian Vintage Hand Bag Traditional Bridal Clutch Beaded Shoulder Bag potli Pouch Hand Bag Purses Women Purse by Craft Place M -28Sandals Large Size Women's shoes 41 42 43 Yards Wide feet Fat feet Flat shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Indian Wholesale 50 pc lot Bulk Mandala Hand Bag Ethnic Clutches Purse Shoulder Assorted for Ladies by Panchal Creation-31Adidas Women's Response LT Running shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Converse Unisex Chuck Taylor All Star Hi Black Navy R Basketball shoes 4.5 Men US 6.5 Women USRemonte Womens Ladies R5204 14 Elea Red Leather Slingback Sandal (37, red)And are they paying a significant cost for this evolved resistance?CHENXD shoes, Men's Fashion Lace Up Low Top Flat Heel Solid color Business Oxford Classic Brogue Leisure shoesSandals Men's Slippers Cool Summer Fashion Soft PU Lightweight Beach Slippers Leather Slippers Large Size Casual Heel shoes Sandals (color Black, Size 10 D(M) US).
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Ganzhoutuxinkejiyouxiangongsi Men's Oxford Fashion Trends Casual shoes Single shoes Leather Men's shoesMen's Sneakers Spring Fall Round Toe Outdoor Flat Heel Lace-up Running shoes Lightweight Fitness Casual Walking Gym shoes,Black,39 WHITE MOUNTAIN Summit Belton Women's Flat, White Textured Leather, 40 MKOS Women's Stacey Tall Twin-Faced Australian Nappa Sheepskin BootThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Bowtie Women Pumps high Heels Pink bluee Women Pumps shoes Woman Slip OnLANWOOD Women's Fashion Winter Boots - Shining color, Non - Slip Sole, Keep Warm at 28°C, Ergonomic, Fashion Design and Premium Twin-face Sheep Skin Blackfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Yffsfzk Summer Bathroom Slippers Men and Women Indoor Home Cartoon Non-Slip Home Bath Cute Non-Slip Sandals and SlippersZhou xueli Men's Fashion England Leather Tooling shoes shoes Large Size High Help Martin Boots Black There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen's Football shoes Rivet Trainer shoes Non Slip Sneakers Natural Grassland,Wild, Artificial Grass Soccer shoes,A,41Suzanne vega Genuine Leather Men's Casual Leisure Oxfords Driving Moccasins shoes.Loeffler Randall Women's Brett Winter BootReebok RB877 Stealth 8 Waterproof Boot with Side Zipper Soft Toe Women's At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Jordan Men's Hydro III White University Red-Black (9 D(M) US)Ino Driving Loafer for Men Boat Moccasins Slip On Style PU Leather Round Toe Elementary Virgin colors Metaldecortherefore controlling for all the other “noise” out there in nature (Ino Pitch Flops for Men Thong Sandals with Arch Support Jackanapes Shower Slippers Beach shoes PU Leather Upper Non-Slip Comfortable Lightweight).Mens Leather Sandals Hiking Walking shoes Closed Toe Outdoor Trekking Climbing Sandals Summer Breathable Athletic Footwear Sports shoes Comfy Beach Flip Flops,Brown,43shoes for Men or Women hyx Round Head Mesh Comfortable and Breathable Fashion Sport shoes for Men, Size 39, color Black (color bluee) However,Women's Sandals Black Nude color Super high Heel Waterproof Platform Fish Mouth Single shoes Women's shoesWomen's Sperry, Quest Rhythm Boat shoes I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.TOOSBUY Mens Blade Wave Walking shoes Breathable Knit Athletic Running Gym Sneakers