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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. CATEDOT Men's Oxford shoes Soft Classic Slip on Peas shoes Lightweight Spring and summer (color Black, Size 7.5UK)The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,OverStone Carnaby Brown Leather 4 Eyelet tie Chukka Ankle Boot UK 8Patent leather Men's Business Stylish comfortable Breathable Oxford Casual Youth Trend Simple Pure color Lace Up Formal shoes Formal wear Dress shoes (color Light Brown, Size 7 UK) Men's Artificial PU Formal shoes Spring Fall Mens Loafers & Slip-Ons Leather shoes Office & Party & Evening Dress shoes (color Black, Size 47)Booties Women Ion Magma 2.5 ES Bootiesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, ANNFENG Fashion Tropical Summer Outdoor Casual Lightweight Waterproof Men's Genuine Leather Beach Slippers, Comfort Elegant Business Leisure Non-slip Soft Flat Sandals shoes Adjustable Backlessand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. LOVDRAM Men's shoes Autumn And Winter New Flying Woven Mesh Breathable Men'S shoes Casual Sports Fashion shoes Sports shoesCgoldnel Tapioca Men’s Rafia grey Nautico Caballero Derbys, GreyWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Men Oxfords Dress shoes Leather Brogue Mens Flats shoes Casual British Style for MenJeff-chy Men's Sports Outdoor Sandals Spring And Summer Men's Sandals Large Size Leather Beach shoes Breathable Leisure Cushion SandalsMzq-yq Summer Breathable Casual shoes, Flying Woven shoes, Deodorant White shoes, Male Korean Version, Wild Low HelpBatman Gear Unisex DEK shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Patent leather Classic Men's Leisure comfort shoes Genuine Leather Slip-on Flat Soft Sole Loafer (Perforation Optional) Formal wear Dress shoes (color Perforation BK, Size 9.5 UK)), then a trematode and a snail (e.g. Handmade Men shoes Microfiber Leather Men Dress shoes Men's Business Casual Classic Gentleman shoes), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, JIAODANBO Autumn New Sports shoes Men'S shoes Wear Breathable Running shoes Fly Woven Mesh Casual Sport shoesand Adidas Originals ZX FLUX Black White Unisex Sneakers shoes Torsion System). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Adidas Predator Absolado Instinct AG Football Boots (Yellow-White-Grey)ZHRUI Men Boat shoes Summer Dress Casual Leather shoes Male Flats Loafers Breathable Moccasin (color bluee, Size 7=41 EU)during experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Faranzi F41095 Oxford shoes for Men Black Patent Snake Print Tuxedo Slip-on Loafer Dress WeddingZHRUI Men shoes Spring Casual Sickle Suede shoes for Men Loafers Soft Breathable Moccasins Slip On shoes (color Red, Size 13=48 EU)Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Men's shoes Feifei Spring and Autumn Keep Warm Movement Leisure Running shoes 3 colors (color Black, Size EU42 UK8.5 CN43)FuweiEncore Casual Men's Sandals Eva Lightweight Non-Slip Female Sandals Dual Use Slippers (color Himmelbluee, Size 38)And are they paying a significant cost for this evolved resistance?Men's Genuine Leather Business Loafers Flat Slip-on Casual Boat shoes Round Toe BreathableLiXiZhong Men's Sandals, Adjustable With Beach Sandals, Breathable Mesh, Sneakers, Casual Outdoor Hiking Sandals (color gold, Size 9.5 UK).
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).FRWANG Smoothy Leather Men's Athletic Sandals Very Lightweight Outdoor Sports Beach shoes Closed Toe SandalsPatent leather Men's fashion shoes Oxford shoes casual comfort low-top shirt patent leather formal shoes (mirror traditional optional) Formal wear Dress shoes (color Black, Size 8 UK) Amblers Safety AS302C PRESELI Unisex Leather Safety Boots BlackDC shoes Reprieve - shoes for Men ADYS100409The costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: ZHRUI Hiking shoes Men Women Waterproof Wear-Resisting Climbing Mountain Sneakers Trekking Boot (color Black bluee, Size 9.5 UK)Made in Spain Men's B-104 Bootsfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Qiusa Men Casual shoes Leather Summer Breathable Holes Flat shoes for Men (color White, Size 5.5=39 EU)DHFUD Men's shoesMen's Casual Fashion Outdoor Closed Toes Leather shoes There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen Dress shoes Pointed Oxfords Leather Lace Up Formal Office Wedding Party Business shoesSummer Beach shoes Men Sandals Split Leather Slippers for Men Slip On Casual shoes Men.U.S. Polo WOUCK Men's Sneakers BrownMen Casual Flip-Flops Summer Beach Daily Comfort Slippers & Flip-Flops Men's Breathable Slippers (color White, Size 42) At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Men Wedding Office Formal shoes Pointed Toe Business Classic Gentleman Dress shoesMen's Sports Outdoor Sandals Summer Beach shoes Leather Casual Breathable Non-Slip Hiking Walking Athletic Velcro Footweartherefore controlling for all the other “noise” out there in nature (Patent leather Men's Oxford shoes pointed PU leather patent leather metal decorative shoes fashion casual low heel shoes Formal wear Dress shoes (color Black, Size 9.5 UK)).Shukun Men's boots Autumn Martin Boots Men'S Leather shoes Military Boots Men'S shoes Tooling Boots In The Wild Wild Short Boots Men'S High HelpDHFUD Leather Strap Casual shoes Men's Casual shoes Men's shoes However,Lelli Kelly Bianco IRIS Scarpa Bambino Sneakers 9830Easy Go Shopping Oxford shoes For Men Brogue shoes Slip On Microfiber Leather Metaldecor Retro Pliable Cricket shoes (color Black Brown, Size 7.5 UK) I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Adidas Men's Ace Tango 17.1 Tf Football Boots